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The tests are simple and the procedure can be performed on the spot in field conditions. These tests use finger-stick or venous blood, the completed test takes a total of 15–20 minutes, and a laboratory is not needed. The threshold of detection by these rapid diagnostic tests is in the range of 100 parasites/μL of blood compared to 5 by ...
Although blood is the sample most frequently used to make a diagnosis, both saliva and urine have been investigated as alternative, less invasive specimens. [2] More recently, modern techniques utilizing antigen tests or polymerase chain reaction have been discovered, though these are not widely implemented in malaria endemic regions.
In the mid-20th century, P. knowlesi became popular as a tool for studying Plasmodium biology and was used for basic research, vaccine research, and drug development. P. knowlesi is still used as a laboratory model for malaria, as it readily infects the model primate the rhesus macaque, and can be grown in cell culture in human or macaque blood.
PlasmoDB [1] is a biological database for the genus Plasmodium. The database is a member of the EuPathDB project. The database contains extensive genome , proteome and metabolome information relating to malaria parasites.
Plasmodium is a eukaryote but with unusual features. The genus Plasmodium consists of all eukaryotes in the phylum Apicomplexa that both undergo the asexual replication process of merogony inside host red blood cells and produce the crystalline pigment hemozoin as a byproduct of digesting host hemoglobin. [2]
Plasmodium vivax is a protozoal parasite and a human pathogen.This parasite is the most frequent and widely distributed cause of recurring malaria. [2] Although it is less virulent than Plasmodium falciparum, the deadliest of the five human malaria parasites, P. vivax malaria infections can lead to severe disease and death, often due to splenomegaly (a pathologically enlarged spleen).
PCR techniques are also commonly used for diagnoses confirmation as well as to separate mixed Plasmodium infections. [2] Even with these techniques, however, it may still be impossible to differentiate infections, as is the case in areas of South America where humans and monkeys coexist and P. malariae and P. brasilianum are not easily ...
The family Plasmodiidae has three sister taxa in the order Haemospororida: the families Garniidae, Haemoproteidae, and Leucocytozoidae.. The Haemoproteidae and the Plasmodiidae both produce pigment, and these have been placed in the suborder Laveraniina.
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