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Exact etiology of PSS is unknown. [2] Since it was first described, A number of noninfectious etiological theories have been proposed including autonomic dysregulation, allergy, variation of developmental glaucoma, autoimmune/HLA-Bw54 and abnormality of the ciliary vasculature. [2]
Endothelin signalling is implicated in the pathophysiology of fibrosis. [26] Vitamin D is implicated in the pathophysiology of the disease. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted, and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune ...
According to a 1956 study, only 0.3% of patients referred for an upper-gastrointestinal-tract barium studies fit this diagnosis, and is thus a rare disease. [29] Recognition of SMA syndrome as a distinct clinical entity is controversial, due in part to its possible confusion with a number of other conditions, [ 30 ] though it is now widely ...
The origins of pathophysiology as a distinct field date back to the late 18th century. The first known lectures on the subject were delivered by Professor August Friedrich Hecker at the University of Erfurt in 1790, and in 1791, he published the first textbook on pathophysiology, Grundriss der Physiologia pathologica [2], spanning 770 pages. [3]
The exact pathophysiology of Monckeberg's arteriosclerosis remains uncertain. However, it is thought that the condition arises from the fatty degeneration of smooth muscle cells within the arterial media, leading to the formation of a mass that undergoes hyaline degeneration and eventually calcification. Typically, this results in minimal ...
Further study may add the presence of these mutations, particularly TET2, to AITL's diagnostic criteria. [67] The prognosis of ATIL has been poor. As rated by the International Prognostic Index (more severe disease with increasing score), 14% of AITL patients presented with an IPI score of 0–1, 59% with a score of 2–3, and 28% with a score ...
Human physiology is the study of bodily functions. Clinical physiology examinations typically involve assessments of such functions as opposed to assessments of structures and anatomy. The specialty encompasses the development of new physiological tests for medical diagnostics.
Pathophysiology is a convergence of pathology with physiology. Pathology is the medical discipline that describes conditions typically observed during a disease state; whereas physiology is the biological discipline that describes processes or mechanisms operating within an organism.
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