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In recent years, gabapentin has seen increased use, particularly in the elderly. [25] There is concern regarding gabapentin's off-label use due to the lack of strong scientific evidence for its efficacy in multiple conditions, its proven side effects and its potential for misuse and physical/psychological dependency. [26] [27] [28]
[6] [12] Existing evidence on the use of gabapentinoids in chronic lower back pain is limited, and demonstrates significant risk of adverse effects, without any demonstrated benefit. [13] The main side-effects include: a feeling of sleepiness and tiredness, decreased blood pressure, nausea, vomiting and also glaucomatous visual hallucinations.
While gabapentin can be helpful in a number of circumstances, some of the common side effects associated with taking the drug as directed include drowsiness, dizziness, headache, dry mouth, weight ...
Some people build tolerance to opioids over time. This requires them to increase their drug dosage to maintain the benefit, and that in turn also increases the unwanted side effects. [78] Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity to pain. [101]
The newer drugs tend to have fewer side effects. [42] For newly diagnosed partial or mixed seizures, there is evidence for using gabapentin, lamotrigine, oxcarbazepine or topiramate as monotherapy. [42] Lamotrigine can be included in the options for children with newly diagnosed absence seizures. [42]
Less common side effects include: delayed gastric emptying, hyperalgesia, immunologic and hormonal dysfunction (hypogonadism is often seen in men taking chronic opioids, but is not always clinically evident), muscle rigidity, and myoclonus. [32] Opiate use for pain is widely accepted in the healthcare system.
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