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Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. [15] Further, studies suggest that users of alendronate have an increase in the numbers of osteoclasts and develop giant, more multinucleated osteoclasts; the significance of this development is unclear. [ 16 ]
Long-term treatment with bisphosphonates produces anti-fracture and bone mineral density effects that persist for 3–5 years after an initial 3–5 years of treatment. [2] The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk of hip fractures by 38% and of vertebral ...
Alendronic acid/colecalciferol, sold under the brand name Fosamax Plus D among others, is a medication for the treatment of osteoporosis in men or in postmenopausal women. [3] [2] [4] [6] Alendronic acid/colecalciferol was approved for use in the United States and in the European Union in 2005. [7] [5]
Staging and Treatment Strategies [7] [48] *Exposed or probable bone in the maxillofacial region without resolution for greater than 8 weeks in patients treated with an antiresorptive and/or an antiangiogenic agent who have not received radiation therapy to the jaws.
Alendronate decreases fractures of the spine but does not have any effect on other types of fractures. [5] Half stop their medications within a year. [174] When on treatment with bisphosphonates rechecking bone mineral density is not needed. [171] There is tentative evidence of benefit in males with osteoporosis. [175]
Combined abaloparatide and alendronate therapy reduced significantly the incidence of vertebral and nonvertebral fractures. [23] A clinical trial assessing the effectiveness of abaloparatide in altering spinal bone mineral density (BMD) in male subjects is expected to start in the first quarter of 2018.
Treatment options have been explored; however, severe cases of ONJ still require surgical removal of the affected bone. [3] A thorough history and assessment of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered.
Osteogenesis imperfecta (IPA: / ˌ ɒ s t i oʊ ˈ dʒ ɛ n ə s ɪ s ˌ ɪ m p ɜːr ˈ f ɛ k t ə /; [4] OI), colloquially known as brittle bone disease, is a group of genetic disorders that all result in bones that break easily.