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Bubaline alphaherpesvirus 1 (BuHV-1) is a species of virus in the genus Varicellovirus, subfamily Alphaherpesvirinae, family Herpesviridae, and order Herpesvirales.
It is very common and contagious; about 67% of the world population under the age of 50 has Herpes simplex virus 1. [5] It is often acquired orally during childhood. It may also be sexually transmitted, including contact with saliva, such as kissing and mouth-to-genital contact ( oral sex ). [ 6 ]
[1] [2] Both HSV-1 and HSV-2 are very common and contagious. They can be spread when an infected person begins shedding the virus. As of 2016, about 67% of the world population under the age of 50 had HSV-1. [3] In the United States, about 47.8% and 11.9% are estimated to have HSV-1 and HSV-2, respectively, though actual prevalence may be much ...
(1) nucleoprotein, (2) DNA, (3) capsid, (4) tegument, (5) envelope, (6) glycoprotein. Click to enlarge. Electron micrograph of various viruses from the Orthoherpesviridae family including Human alphaherpesvirus 3 ( Chickenpox ), Human alphaherpesvirus 1 , and Human alphaherpesvirus 2
Macropodid alphaherpesvirus 1 (MaHV-1) is a species of herpesvirus in the genus Simplexvirus. It was officially accepted as a valid species by the International Committee on Taxonomy of Viruses in 2004.
[11] [13] These "targets" should generally be as unlike any proteins or parts of proteins in humans as possible, to reduce the likelihood of side effects and toxicity. [8] The targets should also be common across many strains of a virus, or even among different species of virus in the same family, so a single drug will have broad effectiveness.
Bovine alphaherpesvirus 1 (BoHV-1) is a virus of the family Herpesviridae and the subfamily Alphaherpesvirinae, known to cause several diseases worldwide in cattle, including rhinotracheitis, vaginitis, balanoposthitis, abortion, conjunctivitis, and enteritis. [1]
However, tumour cells have much weaker PKR-linked defences, which may be the reason why HSV1716 effectively kills a wide range of tumour cell lines in tissue culture. An HSV1716 variant, HSV1716NTR is an oncolytic virus generated by inserting the enzyme NTR into the virus HSV1716 as a GDEPT strategy. [ 4 ]