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National Center for Health Statistics. The prevalence of HSV-1 among persons aged 14–49 was 47.8% (48.1% when adjusted for age) (Figure 1). Prevalence increased linearly with age, from 27.0% among those aged 14–19, to 41.3%, 54.1%, and 59.7% among those aged 20–29, 30–39, and 40–49, respectively.
During 2015–2016, the age-adjusted prevalence of HSV-1 was 48.1% among adolescents and adults aged 14–49 years (50.9% for females and 45.2% for males). Prevalence was higher for females than males in most 2-year periods from 1999–2000 to 2015–2016.
Ages 20 to 29: 7.6% prevalence. Age 30 to 39: 13.3% prevalence. Ages 40 to 49: 21.2% prevalence. In short, the older you get, the more likely the odds of having herpes if you are sexually active and have risk factors for the disease.
An estimated 491.5 million people were living with HSV-2 infection in 2016, equivalent to 13.2% of the world’s population aged 15 to 49 years. HSV-2 is almost exclusively sexually transmitted, causing infection in the genital or anal area (genital herpes).
An estimated 3.8 billion people under age 50 (64.2%) globally have herpes simplex virus type 1 (HSV-1) infection, the main cause of oral herpes. An estimated 519.5 million people aged 15–49 (13.3%) worldwide have herpes simplex virus type 2 (HSV-2) infection, the main cause of genital herpes.
However, as they persist for life, changes in transmission dynamics affect their seroprevalences with variable delays. In the United States, HSV-2 seroprevalence increased between the 1970s and early 1990s, and was projected to increase to 39% among men and 49% among women aged 15–39 by 2025 [20].
The age-adjusted prevalence for the total population is 48.1%. Crude rates are influenced by the underlying age distribution of a population, and age-adjusting the rates assures that differences are not due to the age distribution of the populations being compared.
An estimated 3752.0 million people (95% UI: 3555.5 million-3854.6 million) had HSV type 1 infection at any site, equivalent to a global prevalence of 66.6% in 0-49-year-olds. Differing patterns were observed by age, sex and geographical region, with HSV type 2 prevalence being highest among women and in the WHO African Region.
The World Health Organization (WHO) estimated that 67% (3.7 billion) of people under age 50 have HSV-1, and 13% (491 million) of people between ages 15 and 49 have HSV-2.
Age-specific HSV-2 prevalence data from Central and South America are predominantly for females and show HSV-2 seropositivity generally increasing with age and reaching a maximum of about 50% . Among older women, HSV-2 prevalence appears to increase or plateau with age in most countries.