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Longevity in other animals can shed light on the determinants of life expectancy in humans, especially when found in related mammals. However, important contributions to longevity research have been made by research in other species, ranging from yeast to flies to worms. In fact, some closely related species of vertebrates can have dramatically ...
Longevity medicine is a set of preventive healthcare practices that rely on biomarkers of aging, such as aging clocks, to keep the patient's biological and psychological age as near to peak performance as feasible throughout life. [1] [2] Biogerontology and precision medicine are some of the related fields. [1]
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death.
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. [1]
Cross-links. Crosslinking of DNA; Free radicals – atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other.
By another definition, however, maximum life span corresponds to the age at which the oldest known member of a species or experimental group has died. Calculation of the maximum life span in the latter sense depends upon the initial sample size. [1] Maximum life span contrasts with mean life span (average life span, life expectancy), and longevity.
The Biomarkers of Aging Consortium is currently examining the application of these biomarkers to identify longevity interventions and ways to validate them. [19] Moreover, open-source resources, such as the R package methylCIPHER [ 20 ] and the Python package pyaging [ 21 ] are available to the public as hubs for several biomarkers of aging.
The Nutrition Journal is a peer-reviewed medical journal covering nutrition science. It was established in 2002 and is published by BioMed Central , an imprint of Springer Science+Business Media .