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Nakinra, an anti-IL-1R antibody, has exhibited an anti-neurotoxicity effect on CAR-T treated murine model. Cytokine release syndrome (CRS) Hemophagocytic lymphohistiocytosis, macrophage activation syndrome, and CRS are common side effects after CAR-T treatment. [8] Main articles: Cytokine release syndrome; chimeric antigen receptor T cell.
There are serious side effects that result from CAR T-cells being introduced into the body, including cytokine release syndrome and neurological toxicity. [ 4 ] [ 75 ] Because it is a relatively new treatment, there are few data about the long-term effects of CAR T-cell therapy.
The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel disease. Biological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
CAR-T — or chimeric antigen receptor T cell — therapy uses a patient’s own immune cells to treat certain blood cancers, such as leukemia, multiple myeloma and lymphoma. It involves ...
Dr. Julie Gralow, chief medical officer of the American Society of Clinical Oncology, said, “Based on the available data, the risk of T-cell malignancies due to CAR-T cell therapy appears to be ...
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapy is designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies .