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The cardiotoxicity of anticancer drugs has been well documented, with an entire sub-speciality of cardio-oncology dedicated towards investigating and treating these serious side effects. Two well known anticancer drug families that cause cardiotoxicity are anthracyclines and monoclonal antibodies targeting HER2.
Carfilzomib is derived from epoxomicin, a natural product that was shown by the laboratory of Craig Crews at Yale University to inhibit the proteasome. [8] The Crews laboratory subsequently invented a more specific derivative of epoxomicin named YU101, [9] which was licensed to Proteolix, Inc. Scientists at Proteolix invented a new, distinct compound that had potential use as a drug in humans ...
In 2016, the American College of Cardiology/American Heart Association Task Force recommended it as a replacement for an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction. [10] Potential side effects include angioedema, nephrotoxicity, and low blood pressure. [10]
Checkpoint inhibitor therapy is a form of cancer immunotherapy. The therapy targets immune checkpoints , key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus.
Sleep apnea is an under-recognized risk factor for heart failure. Uncontrolled sleep apnea may increase the risk of heart failure by up to 140%. [4] Weight reduction – through physical activity and dietary modification, as obesity is a risk factor for heart failure and left ventricular hypertrophy. Effective weight management has been shown ...
Milrinone also works to vasodilate which helps alleviate increased pressures on the heart, thus improving its pumping action. While it has been used in people with heart failure for many years, studies suggest that milrinone may exhibit some negative side effects that have caused some debate about its use clinically. [3] [4]
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