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Because many organs can be affected by myeloma, the symptoms and signs vary greatly. Fatigue and bone pain are the most common symptoms at presentation. The CRAB criteria were formerly the benchmark used to establish the presence of active multiple myeloma (as opposed to an earlier, generally asymptomatic, "smoldering" form of the disease).
Many of the signs and symptoms in POEMS syndrome are due at least in part to the release of an aberrant immunoglobulin, i.e. a myeloma protein, as well as certain cytokines by the malignant plasma cells. [9] [3] [4] POEMS syndrome typically begins in middle age – the average age at onset is 50 – and affects up to twice as many men as women.
“The average myeloma patient, independent of race or ethnicity, sees their primary care provider three times with signs and symptoms that are consistent with myeloma before the diagnosis is ...
The five-year survival rate is about 35% in people under 60 years old and 10% in people over 60 years old. [3] Older people whose health is too poor for intensive chemotherapy have a typical survival of five to ten months. [3] It accounts for roughly 1.1% of all cancer cases, and 1.9% of cancer deaths in the United States. [2]
Here are signs your body may be aging early and how to prevent these changes. ... The risk of osteoarthritis increases with age and symptoms typically appear in the late 40s or 50s, experts note ...
Multiple myeloma symptoms. Some people with multiple myeloma have no symptoms. However, those who have symptoms may experience the following, the ACS says: Bone pain and weakness. Low blood counts ...
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