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IRS-1 protein is known to be involved in various types of cancer, including colorectal, [37] lung, [38] prostate and breast cancer. [39] IRS-1 integrates signalling from insulin receptor (InsR), insulin-like growth factor-1 receptor (IGF1R) and many other cytokine receptors and is elevated in β-catenin induced cells.
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. [5] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.
384783 Ensembl ENSG00000185950 ENSMUSG00000038894 UniProt Q9Y4H2 P81122 RefSeq (mRNA) NM_003749 NM_001081212 RefSeq (protein) NP_003740 NP_001074681 Location (UCSC) Chr 13: 109.75 – 109.79 Mb Chr 8: 11.03 – 11.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse For chemical compound with molecular formula IrS 2, see Iridium disulfide. Insulin receptor substrate 2 is a protein that ...
Epithelial cells also exhibit planar cell polarity, in which specialized structures are orientated within the plane of the epithelial sheet. Some examples of planar cell polarity include the scales of fish being oriented in the same direction and similarly the feathers of birds, the fur of mammals, and the cuticular projections (sensory hairs ...
Cell mechanics is a sub-field of biophysics that focuses on the mechanical properties and behavior of living cells and how it relates to cell function. [1] It encompasses aspects of cell biophysics , biomechanics , soft matter physics and rheology , mechanobiology and cell biology .
The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (protein kinase B).
IRS EITC Assistant, which can help determine if one qualifies for EITC; IRS 1040 Instructions 2010, Earned Income Credit instructions on pages 45–48, optional worksheets 49–51, credit table itself 51–58. Only required attachment is Schedule EIC if one is claiming a qualifying child. IRS Schedule EIC. A person or couple claiming qualifying ...
At the cell surface, GLUT4 permits the facilitated diffusion of circulating glucose down its concentration gradient into muscle and fat cells. Once within cells, glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form glucose-6-phosphate , which then enters glycolysis or is polymerized into glycogen.