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If the ingrown toenail recurs despite this treatment, destruction of the germinal matrix with phenol is recommended. [1] As an alternative, one may use 10% sodium hydroxide which is less toxic [2] or trichloroacetic acid which may give faster healing time. [3] Antibiotics are not needed if surgery is performed.
Hydroquinone, also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C 6 H 4 (OH) 2. It has two hydroxyl groups bonded to a benzene ring in a para position.
Phenol spray, with phenol as the active ingredient, is used medically to treat sore throat. [38] It is the active ingredient in some oral analgesics. [38] Concentrated phenol liquids are used for permanent treatment of ingrown toe and finger nails, a procedure known as a chemical matrixectomy. The procedure was first described by Otto Boll in 1945.
Phenol is readily alkylated at the ortho positions using alkenes in the presence of a Lewis acid such as aluminium phenoxide: [citation needed] CH 2 =CR 2 + C 6 H 5 OH → R 2 CHCH 2 -2-C 6 H 4 OH More than 100,000 tons of tert-butyl phenols are produced annually (year: 2000) in this way, using isobutylene (CH 2 =CMe 2 ) as the alkylating agent.
A phenol-croton oil is a type of chemical peel. [7] The term "phenol-croton oil peel" has replaced the vague term "phenol peel" in medical literature. It was originally used on a clandestine basis by early Hollywood stars in the 1920s and was incorporated into mainstream practice in the 1960s by Thomas Baker and Howard Gordon. [8]
In 1834, German chemist Friedlieb Ferdinand Runge discovered a phenol, also known as carbolic acid, which he derived in an impure form from coal tar.In August 1865, Joseph Lister applied a piece of lint dipped in carbolic acid solution to the wound of an eleven-year-old boy at Glasgow Royal Infirmary, who had sustained a compound fracture after a cart wheel had passed over his leg.
[1] [5] [6] [7]: 104 Some phenols are germicidal and are used in formulating disinfectants. Phenol – the simplest of the phenols Chemical structure of salicylic acid, the active metabolite of aspirin Chemical structure of aloe emodin, a diphenol Quercetin, a typical flavonoid, is a polyphenol Tannic acid, a typical polyphenol of indeterminate ...
Substrates containing two phenols (or an aniline and a phenol; see equation (8) below for a related example), undergo oxidative coupling in the presence of hypervalent iodine(III) reagents. Coupling of both the ortho and para positions is possible; however, the use of bulky silyl-protected phenols provides complete selectivity for para coupling ...