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  2. Furosemide - Wikipedia

    en.wikipedia.org/wiki/Furosemide

    Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. [4] Furosemide may also be used for the treatment of high blood pressure . [ 4 ]

  3. Loop diuretic - Wikipedia

    en.wikipedia.org/wiki/Loop_diuretic

    Loop diuretics usually have a ceiling effect whereby doses greater than a certain maximum amount will not increase the clinical effect of the drug. Also, there is a threshold minimum concentration of loop diuretics that needs to be achieved at the thick ascending limb to enable the onset of abrupt diuresis.

  4. Drug-induced QT prolongation - Wikipedia

    en.wikipedia.org/wiki/Drug-induced_QT_prolongation

    Structural heart disease, such as heart failure, myocardial infarction, and left ventricular hypertrophy, are also risk factors. Diuretic-induced hypokalemia and/or hypomagnesemia taken for heart failure can induce proarrthymia. The ischemia that results from myocardial infarctions also induce QT prolongation. [citation needed]

  5. Alcoholic cardiomyopathy - Wikipedia

    en.wikipedia.org/wiki/Alcoholic_cardiomyopathy

    Unfortunately, for patients that require heart transplants, cardiomyopathy due to alcoholism has the lowest post-heart transplant survival out of all causes of cardiomyopathy. [11] Per one study that compared 224 alcoholic cardiomyopathy patients to over 60,000 non-alcoholic cardiomyopathy patients, survival post heart transplant was less at 1 ...

  6. Daphnia - Wikipedia

    en.wikipedia.org/wiki/Daphnia

    The heart is at the top of the back, just behind the head, and the average heart rate is about 180 bpm under normal conditions. Daphnia spp., like many animals, are prone to alcohol intoxication, and make excellent subjects for studying the effects of the depressant on the nervous system due to the translucent exoskeleton and the visibly ...

  7. Bainbridge reflex - Wikipedia

    en.wikipedia.org/wiki/Bainbridge_reflex

    The Bainbridge reflex is most strong when heart rate is low; when heart rate is already high, additional venous return to the right atrium (i.e. additional increases in blood volume) will indirectly cause relatively greater stimulation of arterial baroreceptors which will reduce the heart rate. Thus, the effect of the Bainbridge reflex on heart ...

  8. Acute decompensated heart failure - Wikipedia

    en.wikipedia.org/wiki/Acute_decompensated_heart...

    Cardiac symptoms of heart failure include chest pain/pressure and palpitations.Common noncardiac signs and symptoms of heart failure include loss of appetite, nausea, weight loss, bloating, fatigue, weakness, low urine output, waking up at night to urinate, and cerebral symptoms of varying severity, ranging from anxiety to memory impairment and confusion.

  9. Muscarinic acetylcholine receptor M2 - Wikipedia

    en.wikipedia.org/wiki/Muscarinic_acetylcholine...

    [13] [14] In the heart, this contributes to a decreased heart rate. They do so by the G βγ subunit of the G protein; G βγ shifts the open probability of K + channels in the membrane of the cardiac pacemaker cells, which causes an outward current of potassium, effectively hyperpolarizing the membrane, which slows down the heart rate.