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Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. [4] Furosemide may also be used for the treatment of high blood pressure. [4] It can be taken intravenously or orally. [4]
Loop diuretics usually have a ceiling effect whereby doses greater than a certain maximum amount will not increase the clinical effect of the drug. Also, there is a threshold minimum concentration of loop diuretics that needs to be achieved at the thick ascending limb to enable the onset of abrupt diuresis.
The term "calcium-sparing diuretic" is sometimes used to identify agents that result in a relatively low rate of excretion of calcium. [5] The reduced concentration of calcium in the urine can lead to an increased rate of calcium in serum. The sparing effect on calcium can be beneficial in hypocalcemia, or unwanted in hypercalcemia. [citation ...
Some drugs and medications affect heart rate, meaning you may have a lower maximum heart rate and target zone, says Dr. Steinbaum. “If you have a heart condition or take medication, ask your ...
Cardiovascular agents are drugs that affect the rate and intensity of cardiac contraction, blood vessel diameters, blood volume, blood clotting and blood cholesterol levels. [1] They are indicated to treat diseases related to the heart or the vascular system (blood vessels), such as hypertension , hyperlipidemia , coagulation disorders , heart ...
Tolvaptan and conivaptan antagonize the effects of antidiuretic hormone (vasopressin), thereby promoting the specific excretion of free water, directly ameliorating the volume overloaded state, and counteracting the hyponatremia that occurs due to the release of neuroendocrine hormones in an attempt to counteract the effects of heart failure.
Medications like diuretics and antidepressants can increase the blood pressure-lowering effects of minoxidil. However, interactions are more likely with oral minoxidil than topical minoxidil.
Reverse use dependent drugs that slow heart rate (such as quinidine) can be less effective at high heart rates. [11] The refractoriness of the ventricular myocyte increases at lower heart rates . [ citation needed ] This increases the susceptibility of the myocardium to early Afterdepolarizations (EADs) at low heart rates.