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  2. Indole-3-carbaldehyde - Wikipedia

    en.wikipedia.org/wiki/Indole-3-carbaldehyde

    Lactobacillaceae (Lactobacillus s.l.) species metabolize tryptophan into indole-3-aldehyde (I3A) which acts on the aryl hydrocarbon receptor (AhR) in intestinal immune cells, in turn increasing interleukin-22 (IL-22) production. [2] Indole itself triggers the secretion of glucagon-like peptide-1 (GLP-1) in intestinal L cells and acts as a ...

  3. Indole - Wikipedia

    en.wikipedia.org/wiki/Indole

    Indole is an organic compound with the formula C 6 H 4 CCNH 3. Indole is classified as an aromatic heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole where one or more of the hydrogen atoms have been replaced by substituent groups.

  4. Biological activity - Wikipedia

    en.wikipedia.org/wiki/Biological_activity

    In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. [1] [2] When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents. Among the various properties of ...

  5. Indoleacetate decarboxylase - Wikipedia

    en.wikipedia.org/wiki/Indoleacetate_decarboxylase

    The decarboxylation of indole-3-acetate is chemically difficult since it leaves an unstable carbanion because of the direct elimination of CO 2. This chemical reaction is promoted by 1-electron oxidation of indole-3-acetate through a proton-coupled electron transfer (PCET), which requires the transfer of the indolic-NH proton to a suitably ...

  6. Indole alkaloid - Wikipedia

    en.wikipedia.org/wiki/Indole_alkaloid

    Indole alkaloids are distinguished depending on their biosynthesis. The two types of indole alkaloids are isoprenoids and non-isoprenoids. The latter include terpenoid structural elements, synthesized by living organisms from dimethylallyl pyrophosphate (DMAPP) and/or isopentenyl pyrophosphate (IPP): [8] Non-isoprenoid: Simple derivatives of indole

  7. Indolepyruvate decarboxylase - Wikipedia

    en.wikipedia.org/wiki/Indolepyruvate_decarboxylase

    The enzyme indolepyruvate decarboxylase (EC 4.1.1.74) catalyzes the chemical reaction. 3-(indol-3-yl)pyruvate 2-(indol-3-yl)acetaldehyde + CO 2. This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds.