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Ankylosing spondylitis (AS) is a type of arthritis from the disease spectrum of axial spondyloarthritis. [5] It is characterized by long-term inflammation of the joints of the spine, typically where the spine joins the pelvis. [2] With AS, eye and bowel problems—as well as back pain—may occur. [2]
Ankylosing spondylitis: AS Asperger syndrome: ASCVD Atherosclerotic cardiovascular disease: ASD Atrial septal defect: ASD(s) Autism spectrum disorders: ASHF Acute systolic heart failure ASS African sleeping sickness: A-T Ataxia-telangiectasia: AVMs Arteriovenous malformations
HLA-B27 is a polymorphic form of the HLA-B molecule found in up to 95% of people with ankylosing spondylitis of European ancestry, [16] [17] 70% with reactive arthritis, [18] 60% with psoriatic spondylitis, [12] 25% with peripheral psoriatic arthritis, [17] and 70% with spondylitis associated with inflammatory bowel disease.
More than 80% of patients with the ankylosing spondylitis variant test positive for the HLA-B27 biomarker, but not everyone with this biomarker will develop disease. [22] Some people with axial spondyloarthritis may test positive for elevated C-reactive protein , or CRP, depending on their disease activity. [ 22 ]
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Spondylitis is an inflammation of the vertebrae. It is a form of spondylopathy . In many cases, spondylitis involves one or more vertebral joints , as well, which itself is called spondylarthritis .
Along with reactive arthritis, psoriatic arthritis, and idiopathic ankylosing spondylitis, this type of arthritis is categorized as a seronegative spondyloarthropathy. [4] Other gastrointestinal disorders like Whipple's disease, celiac disease, and intestinal bypass surgery for severe obesity can also cause joint involvement. The pathogenesis ...
When involving inflammation, it can be called spondylitis. In contrast, a spondyloarthropathy is a condition involving the vertebral joints, but many conditions involve both spondylopathy and spondyloarthropathy. Examples include ankylosing spondylitis and spondylosis.