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In preclinical studies, nicotine vaccines have demonstrated the ability to combat the negative effects of nicotine abuse, but none of the developed vaccines has been authorized for use in clinical trials as a smoking cessation strategy. [4] Theoretically, the decrease of nicotine's rewarding effects should result in smoking cessation.
A 2018 study funded by DOH Ireland set out with an objective to determine if Allen Carr's Easyway to Stop Smoking was superior to Quit.ie in a randomised clinical trial. Quit.ie is an online portal for smoking cessation. The Allen Carr method was implemented in group sessions.
The trial enrolled a total of 301 heavy smokers who smoked an average of 24 cigarettes per day prior to enrollment. [11] Nabi issued a press release indicating that phase IIB testing was a success, showing statistically significant rates of smoking cessation and continuous long-term smoking abstinence during the trial period. [12] [10]
Clinical trials studying hypnosis and hypnotherapy as a method for smoking cessation have been inconclusive. [ 46 ] : 100 [ 139 ] [ 140 ] [ 141 ] A Cochrane review was unable to find evidence of benefit of hypnosis in smoking cessation, and suggested if there is a beneficial effect, it is small at best. [ 139 ]
Jed Eugene Rose is an American academic professor, [1] inventor [2] and researcher in the field of nicotine and smoking cessation. Rose is presently the President and CEO of the Rose Research Center, LLC in Raleigh, North Carolina. [3] Additionally, he is the Director of the Duke Center for Smoking Cessation at Duke University Medical Center. [4]
Efficacy studies, which are conducted using randomized controlled trials, do not transfer very well to real-world effectiveness. Bauld, Bell, McCullough, Richardson and Greaves (2009) reviewed 20 studies on the effectiveness of intensive NHS treatments for smoking cessation published between 1990 and 2007. [26]
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