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The latency stage involves few or no symptoms and can last anywhere from two weeks to twenty years or more, depending on the individual. AIDS, the final stage of HIV infection, is defined by low CD4+ T cell counts (fewer than 200 per μL), various opportunistic infections, cancers, and other conditions.
Without treatment, this second stage of the natural history of HIV infection can last from about three years [34] to over 20 years [35] (on average, about eight years). [36] While typically there are few or no symptoms at first, near the end of this stage many people experience fever, weight loss, gastrointestinal problems and muscle pains. [1]
The reason for the preferential loss of mucosal CD4 + T cells is that a majority of mucosal CD4 + T cells express the CCR5 coreceptor, whereas a small fraction of CD4 + T cells in the bloodstream do so. [5] HIV seeks out and destroys CCR5 expressing CD4 + cells during acute infection. A vigorous immune response eventually controls the infection ...
The asymptomatic or clinical latency phase is marked by slow replication of the HIV virus, followed by steady depletion of CD4 T cells with little to no symptoms. For individuals that are rapid progressors, this phase can be short lived, with an average of 2-3 years. Long-term progressors (LTNPS) can remain stable in this stage for over a ...
Conditions where a presumptive diagnosis can be made on the basis of clinical signs or simple investigations [citation needed] Unexplained chronic diarrhoea for longer than one month; Unexplained persistent fever (intermittent or constant for longer than one month) Severe weight loss (>10% of presumed or measured body weight) Oral candidiasis
Human Immunodeficiency Virus (HIV) has the capability to enter a latent stage of infection where it exists as a dormant provirus in CD4+ T-cells.Most latently infected cells are resting memory T cells, [1] however a small fraction of latently infected cells isolated from HIV patients are naive CD4 T cells.
Following infection with HIV-1, the rate of clinical disease progression varies between individuals.Factors such as host susceptibility, genetics and immune function, [1] health care and co-infections [2] as well as viral genetic variability [3] may affect the rate of progression to the point of needing to take medication in order not to develop AIDS.
Disease-specific drugs can also alleviate symptoms of AIDS and even cure specific AIDS-defining conditions in some cases. Medical treatment can reduce HIV infection in many cases to a survivable chronic condition. However, these advances do not constitute a cure, since current treatment regimens cannot eradicate latent HIV from the body.