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2. Serotonin–norepinephrine reuptake inhibitor - Wikipedia

   en.wikipedia.org/wiki/Serotonin–norepinephrine...

   Clinical studies suggest that compounds that increase the concentration in the synaptic cleft of both norepinephrine and serotonin are more successful than single acting agents in the treatment of depression, but the data is not conclusive whether SNRIs are a more effective treatment option over SSRIs for depression. [32] [33] [34]

3. Breakthrough antidepressants with fewer side effects could ...

   www.aol.com/finance/breakthrough-antidepressants...

   What’s more, once a person has tried two different antidepressants, stayed with each one for long enough to feel the effects, and doesn’t get relief, their depression is considered treatment ...

4. Antidepressant treatment tachyphylaxis - Wikipedia

   en.wikipedia.org/wiki/Antidepressant_treatment_t...

   Antidepressant treatment tachyphylaxis (ADT tachyphylaxis), also known as Prozac poop-out, is a medical condition in which progressive or acute tolerance effects are seen following chronic administration of a drug. [1] It occurs more often with Selective serotonin reuptake inhibitors (SSRIs), which are the most commonly prescribed antidepressants.

5. Management of depression - Wikipedia

   en.wikipedia.org/wiki/Management_of_depression

   The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

6. Vortioxetine - Wikipedia

   en.wikipedia.org/wiki/Vortioxetine

   Common side effects include nausea, dry mouth, diarrhea, constipation, vomiting (3-6% of people), and sexual dysfunction. [15] [11] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and SIADH. [15] A withdrawal syndrome may occur if the medication is abruptly stopped or the dose is ...

7. Tianeptine - Wikipedia

   en.wikipedia.org/wiki/Tianeptine

   Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. [19] It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. [ 10 ]