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These LPC analogues are metabolically stable, and several ALPs such as edelfosine, miltefosine and perifosine are under research and development as drugs against cancer and other diseases. [ 6 ] [ 7 ] Lysophosphatidylcholine processing has been discovered to be an essential component of normal human brain development: those born with genes that ...
Choline is used to synthesize acetylcholine, a neurotransmitter involved in muscle control and numerous functions of the nervous system. [2] [3] Choline is involved in early development of the brain, gene expression, cell membrane signaling, and brain metabolism. [3]
L-α-Glycerophosphorylcholine (alpha-GPC, choline alfoscerate, sn-glycero-3-phosphocholine) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor [ 1 ] which has been investigated for its potential for the treatment of Alzheimer's disease [ 2 ] and other dementias .
1-Oleoyl-2-palmitoyl-phosphatidylcholine. Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup.They are a major component of biological membranes and can easily be obtained from a variety of readily available sources, such as egg yolk or soybeans, from which they are mechanically or chemically extracted using hexane.
Structures and localization of the enzymes in the CDP-choline pathway. [1]: 415 The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules.
This reaction is important for the synthesis of phosphatidylcholine containing specific fatty acids, but are not used for the de-novo synthesis of phosphatidylcholine. [ 4 ] [ 12 ] In contrast to these finding from rat liver microsomes, mammalian acyl transferase from dog lungs was found to exhibit no preference between 1-lyso-2-acyl ...