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Amlodipine/olmesartan, sold under the brand name Azor, among others is a fixed-dose combination medication used to treat high blood pressure. [5] It contains amlodipine , as the besilate, a dihydropyridine calcium channel blocker , and olmesartan medoxomil , an angiotensin II receptor blocker .
Amlodipine has been studied in healthy volunteers following oral administration of 14 C-labelled drug. [53] Amlodipine is well absorbed by the oral route with a mean oral bioavailability around 60%; the half-life of amlodipine is about 30 h to 50 h, and steady-state plasma concentrations are achieved after 7 to 8 days of daily dosing. [7]
It contains olmesartan medoxomil, an angiotensin II receptor blocker, amlodipine, as the besilate, a calcium channel blocker, and hydrochlorothiazide, a thiazide diuretic. [3] It is taken by mouth . [ 3 ]
In pooled data, from three comparative studies conducted in 200 patients with mild to moderate hypertension, 2.5 mg of levamlodipine was found to be equivalent in its blood pressure lowering efficacy to 5 mg of amlodipine. The average reduction in systolic BP was 19±3 vs 19±4, 20±2 vs 19±3 and 20±2 vs 19±3 mm of Hg recorded in standing ...
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Amlodipine/celecoxib, sold under the brand name Consensi, is a fixed-dose combination medication used to treat both hypertension and osteoarthritis at the same time in adults. [ 1 ] [ 2 ] It contains amlodipine , as the besilate, and celecoxib . [ 1 ]
Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure. [1] It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor. [1] It may be used if a single agent is not sufficient. [1]
Amlodipine/valsartan, sold under the brand name Exforge among others, is a blood pressure lowering combination drug. It contains amlodipine , as the besilate, a dihydropyridine -type calcium channel blocker , and valsartan , an angiotensin II receptor antagonist . [ 6 ]