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The mononuclear spot test or monospot test, a form of the heterophile antibody test, [1] is a rapid test for infectious mononucleosis due to Epstein–Barr virus (EBV). It is an improvement on the Paul–Bunnell test. [2] The test is specific for heterophile antibodies produced by the human immune system in response to EBV infection.
Heterophile antibodies can arise in non-EBV infections. False positive monospot tests may occur in cases of HIV, lymphoma, or systemic lupus erythematosus. Other assays for detection of EBV are available, including serologic markers. [7] An important clinical pearl for heterophile antibodies is they can also be seen in genetic immunodeficiencies.
Prior infectious mononucleosis has been linked to the development of multiple sclerosis. [65] Hematologic: Hemolytic anemia (direct Coombs test is positive) and various cytopenias, and bleeding (caused by thrombocytopenia) can occur. [43] Mild jaundice; Hepatitis with the Epstein–Barr virus is rare.
The kinetoplast fluoresces if serum contains high avidity anti-dsDNA antibodies. This test has a higher specificity than EIA because it uses unprocessed DNA. Processed DNA can contain regions of ssDNA, allowing detection of anti-ssDNA antibodies, which can give false positive results. [1] [28]
A false positive Covid-19 test result can happen, but it’s rare, says Brian Labus, Ph.D., M.P.H., assistant professor at the University of Nevada Las Vegas School of Public Health.
False positives can occur due to the test reacting to, or detecting, an antibody that happens to be sufficiently similar in structure to the target antibody. Antibodies are generated randomly, so the immune system has a low chance of generating an antibody capable of weakly binding to the assay by coincidence.
False positive COVID-19 tests occur when you don’t have the novel coronavirus, but the test is positive. Experts explain how and why false positives happen.
The 46-year-old reality star explained, “It is the same hormone that is produced when a woman is pregnant resulting in the false positive.” She noted, however, that having kids in the future ...