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The study demonstrating the effectiveness of magnesium sulfate for the management of eclampsia was first published in 1955. [57] Effective anticonvulsant serum levels range from 2.5 to 7.5 mEq/L, [ 58 ] however the ideal dosing regime (dose, route of administration, timing of dosing) to prevent and treat eclampsia is not clear.
Magnesium sulfate is effective in decreasing the risk that pre-eclampsia progresses to eclampsia. [24] Intravenous magnesium sulfate is used to prevent and treat seizures of eclampsia. It reduces the systolic blood pressure but does not alter the diastolic blood pressure, so the blood perfusion to the fetus is not compromised.
As a bronchodilator after beta-agonist and anticholinergic agents have been tried, e.g. in severe exacerbations of asthma. [4]Obstetrics: Magnesium sulfate is used to prevent seizures in women with preeclampsia and eclampsia, and is also used for fetal neuroprotection in preterm deliveries, but has been shown to be an ineffective tocolytic agent.
The intrapartum and postpartum administration of magnesium sulfate is recommended in severe pre-eclampsia for the prevention of eclampsia. [4] [15] Further, magnesium sulfate is recommended for the treatment of eclampsia over other anticonvulsants. [4] Magnesium sulfate acts by interacting with NMDA receptors. [53]
Magnesium sulfate or magnesium sulphate is a chemical compound, a salt with the formula MgSO 4, consisting of magnesium cations Mg 2+ (20.19% by mass) and sulfate anions SO 2− 4. It is a white crystalline solid , soluble in water but not in ethanol .
Commonly used tocolytic medications include β 2 agonists, calcium channel blockers, NSAIDs, and magnesium sulfate. These can assist in delaying preterm delivery by suppressing uterine muscle contractions and their use is intended to reduce fetal morbidity and mortality associated with preterm birth. [ 2 ]
6.1 Mechanism of action. 6.2 Nutrition. ... Intravenous magnesium sulfate is used for the management of pre-eclampsia and eclampsia. [124] ...
Magnesium can also be toxic to plants, although this is typically seen only in drought conditions. [47] [48] Space-filling model of the chlorophyll a molecule, with the magnesium ion (bright-green) visible at the center of the chlorin group. In animals, magnesium deficiency (hypomagnesemia) is seen when the environmental availability of ...