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Desktopmodells of SPECT, uCT and PET for preclinical use. Preclinical imaging is the visualization of living animals for research purposes, [1] such as drug development. . Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental c
Preclinical or small-animal Single Photon Emission Computed Tomography is a radionuclide based molecular imaging modality for small laboratory animals [1] (e.g. mice and rats). Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm ...
Combining complementary information from different imaging modalities. An example is the fusion of anatomical and functional information. Since the size and shape of structures vary across modalities, it is more challenging to evaluate the alignment quality. This has led to the use of similarity measures such as mutual information. [25]
Electron resonance imaging (ERI) is a preclinical imaging method, together with positron emission tomography (PET), computed tomography scan (CT scan), magnetic resonance imaging (MRI), and other techniques. ERI is dedicated to imaging small laboratory animals, and its unique feature is the ability to detect free radicals.
Like magnetic resonance imaging, CT scans use numerous methods to display and measure data, including sequential CT (where the CT table steps from location to location), spiral CT (where the entire X-ray tube is spun around the subject), and electron beam tomography (where only the electron paths are spun using deflection coils).
This imaging modality uses a wide beam of X-rays for image acquisition and is the first imaging technique available in modern medicine. Fluoroscopy produces real-time images of internal structures of the body in a similar fashion to radiography , but employs a constant input of X-rays, at a lower dose rate.
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