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In this application, biomarkers act as stand-ins for the effects of a drug on cancer progression and survival. Ideally, the use of validated biomarkers would prevent patients from having to undergo tumor biopsies and lengthy clinical trials to determine if a new drug worked. In the current standard of care, the metric for determining a drug's ...
Drug resistance, where cancer cells develop resistance to BRAF inhibitors over time, remains a significant hurdle, leading to the need for combination therapies and next-generation inhibitors. Another dynamic shaping the BRAF inhibitor market is the competitive landscape, which has intensified with the entry of new drugs and combination therapies.
It screens patients for microsatellite instability (MSI), which is a key genomic biomarker in colorectal cancer. [10] MSIntuit CRC is approved for use across the European Union. [ 11 ] It underwent a blind validation in 2023, made possibly partly by its availability within Medipath, the largest pathology lab network in France.
The researchers suggest that their findings should be confirmed in clinical trials to determine whether they could form the basis of a new treatment for this hard-to-treat type of breast cancer.
The mRNA-based disease diagnosis technologies have been applied to medical field widely in recent years, especially on early diagnosis of tumors (such as renal cell carcinoma, [2] hepatocellular carcinoma, [3] [4] breast cancer [5] and prostate cancer [6]). The technology can be applied to various types of samples depending on how easily the ...
Nasief et al. (2019) [20] showed that changes of radiomic features over time in longitudinal images (delta-radiomic features, DRFs) can potentially be used as a biomarker to predict treatment response for pancreatic cancer. Their results showed that a Bayesian regularization neural network can be used to identify a subset of DRFs that ...