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A beating heart awaiting transplant. American medical researcher Simon Flexner was one of the first people to mention the possibility of heart transplantation. In 1907, he wrote the paper "Tendencies in Pathology," in which he said that it would be possible one day by surgery to replace diseased human organs – including arteries, stomach, kidneys and heart.
If the organ donor is human, most countries require that the donor be legally dead for consideration of organ transplantation (e.g. cardiac death or brain death). For some organs, a living donor can be the source of the organ. For example, living donors can donate one kidney or part of their liver to a well-matched recipient. [2]
The donor heart and lungs are positioned and sewn into place. As the donor organs warm up to body temperature, the lungs begin to inflate. The heart may fibrillate at first - this occurs because the cardiac muscle fibres are not contracting synchronously. Internal paddles can be used to apply a small electric shock to the heart to restore ...
Canadian centers have a heart transplantation policy matching the proposed policy in the United States. [3] Intentional ABOi heart transplantation in infants was conceived in the 1960s by Adrian Kantrowitz, [13] with clinical evidence first being shown by Leonard L. Bailey's team in the mid-1980s, which he termed "immunologic privilege."
Similar to the concept of elective cardiopulmonary bypass, used in open heart surgery, oxygenation and perfusion can be maintained with an ECMO device in patients undergoing cardiovascular collapse. In the setting of cardiac arrest, ECPR involves percutaneous cannulation of a femoral vein and artery, followed by the activation of the device ...
This publication laid the groundwork for CIOMS' 1982, 1993, 2002, 2009, and 2016 versions of International Ethical Guidelines for Health-Related Research Involving Humans. [3] These guidelines have been praised for including diverse stakeholders from low- and middle-income countries, compared to the Declaration of Helsinki written by physicians ...
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For example, with heart and lung transplantation, candidate recipients are given one of four status levels (1A - the highest level, 1B, 2, and 7). [18] A matching born (i.e. not in utero ) candidate of Status 1A within the donor region, of matching ABO type, and within 500 miles will be given the highest priority, with multiple matches being ...