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Micrograph showing apocrine metaplasia of the breast with typical features, [4] including apical snouts with eosinophilic granules. H&E stain. Apocrine metaplasia is a reversible transformation of cells to an apocrine phenotype. It is common in the breast in the context of fibrocystic change. It is seen in women mostly over the age of 50 years.
Micrograph showing apocrine metaplasia of the breast with typical features [3] H&E stain. Barrett's esophagus is an abnormal change in the cells of the lower esophagus, thought to be caused by damage from chronic stomach acid exposure. The following table lists some common tissues susceptible to metaplasia, and the stimuli that can cause the ...
Micrograph showing apocrine-type metaplasia of the breast with typical oncocytes. [2] H&E stain. Oncocytes (left of image), as seen in a renal oncocytoma. H&E stain. An oncocyte is an epithelial cell characterized by an excessive number of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. Oncocytes can be benign or malignant.
The cell line is a great model for breast cancer cells because the cells proliferate at a fast rate and is stimulated by androgens, but inhibited by progesterone, estrogen, and Her-2 receptors. The specific mutation that contributes to the cell cancer line is a glutamate to histidine change found on exon 7; more specifically, the amino acid 865.
While there is no consensus on the criteria used for its diagnosis, ADCIS is most often defined as a non-invasive breast tumor consisting of lactiferous ducts that are filled with neoplastic apocrine cells; [4] the cells in these tumors, similar to those in PACB, are estrogen receptor-negative, progesterone-receptor negative, and, in at least ...
Apocrine metaplasia. Pathology Outlines. Last author update: 28 May 2020; Author: Mikael Häggström, M.D. Author info - Reusing images - Conflicts of interest:
They lie between the basement membrane and glandular epithelium. Each cell consists of a cell body from which 4-8 processes radiate and embrace the secretory unit. Myoepithelial cells have contractile functions. They help in expelling secretions from the lumen of secretory units and facilitate the movement of saliva in salivary ducts.
The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under stress. [2] The term goblet refers to the cell's goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucus laden granules; its basal portion ...