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Flucytosine is used by mouth and by injection into a vein. [2] [3] Common side effects include bone marrow suppression, loss of appetite, diarrhea, vomiting, and psychosis. [2] Anaphylaxis and other allergic reactions occasionally occur. [2] It is unclear if use in pregnancy is safe for the baby. [4]
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Common side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough. [8] Common side effects when used in the nose include nosebleeding and sore throat. [ 9 ] Unlike fluticasone furoate , which is approved in children as young as two years of age when used for allergies, fluticasone propionate is only ...
Other serious side effects include low blood potassium and myocarditis (inflammation of the heart). [3] It appears to be relatively safe in pregnancy. [4] There is a lipid formulation that has a lower risk of side effects. [4] It is in the polyene class of medications and works in part by interfering with the cell membrane of the fungus. [3] [4]
In 1970, flucytosine was available in Africa. [35] A dose of 200 mg/kg per day of flucytosine is associated with more side effects but is not more effective. [citation needed] A single high dose of liposomal amphotericin B with 14 days of flucytosine and fluconazole is recommended by the newest WHO guideline for cryptococcal meningitis. [36]
Before oral antifungal therapies are used to treat nail disease, a confirmation of the fungal infection should be made. [36] Approximately half of suspected cases of fungal infection in nails have a non-fungal cause. [36] The side effects of oral treatment are significant and people without an infection should not take these drugs. [36]
Oral potassium iodide; Potassium iodide is an anti-fungal drug that is widely used as a treatment for cutaneous sporotrichosis. Despite its wide use, there is no high-quality evidence for or against this practice. Further studies are needed to assess the efficacy and safety of oral potassium iodide in the treatment of sporotrichosis. [14]
Other side effects of gold-containing drugs include kidney damage, itching rash, and ulcerations of the mouth, tongue, and pharynx. Approximately 35% of patients discontinue the use of gold salts because of these side effects. Kidney function must be monitored continuously while taking gold compounds. [5]