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Kawasaki disease (also known as mucocutaneous lymph node syndrome) is a syndrome of unknown cause that results in a fever and mainly affects children under 5 years of age. [6] It is a form of vasculitis , in which medium-sized blood vessels become inflamed throughout the body. [ 1 ]
Kawasaki disease is most commonly seen in infants and children under five years old and is more likely to affect boys. The disease is self-limited which means that the inflammation will resolve after 6 to 8 weeks but if we left it untreated, there is a 20-25% risk of the heart complications we went over. Alright so let’s look at the symptoms ...
Early diagnosis of Kawasaki disease prevents the condition becoming life-threatening, as it can cause aneurysms in the coronary arteries. [6] Children who suffer from it can develop atherosclerosis. It is unclear what causes Kawasaki disease, but it has been reported to be more common in children of Asian descent. [6] Japan and South Korea have ...
IFN-α is another product of prolonged SAg exposure. This cytokine is closely linked with induction of autoimmunity, [21] and the autoimmune disease Kawasaki disease is known to be caused by SAg infection. [14] SAg activation in T-cells leads to production of CD40 ligand which activates isotype switching in B cells to IgG and IgM and IgE. [22]
Kawasaki disease – Affects medium-sized vessels mostly seen in young children with myocarditis, & pericarditis, and is the most common cause of acquired heart disease in children (results in coronary artery aneurysms). Myocardial infarction from coronary thrombosis is the most common cause of death from Kawasaki disease.
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Tomisaku Kawasaki (川崎 富作, Kawasaki Tomisaku, February 1, 1925 – June 5, 2020) was a Japanese pediatrician who first described the condition now known as Kawasaki disease in the 1960s. [ 1 ] [ 2 ] Alongside rheumatic heart disease , Kawasaki disease is considered to be the leading cause of acquired heart disease in children worldwide.
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions. [13] [14] These conditions include primary immunodeficiency, immune thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease, certain cases of HIV/AIDS and measles, Guillain–Barré syndrome, and certain other infections when a ...