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Peptide amphiphiles were developed in the 1990s. They were first described by the group of Matthew Tirrell in 1995. [5] [6] These first reported PA molecules were composed of two domains: one of lipophilic character and another of hydrophilic properties, which allowed self-assembly into sphere-like supramolecular structures as a result of the association of the lipophilic domains away from the ...
These assemblies have shown promise as agents of drug delivery to cancer cells. Encapsulation can control reactivity. For instance, excited state reactivity of free 1-phenyl-3-tolyl-2-proponanone (abbreviated A-CO-B) yields products A-A, B-B, and AB, which result from decarbonylation followed by random recombination of radicals A• and B•.
With the excellent nature in biodegradation and biocompatibility, supramolecular polymers show great potential in the development of drug delivery, gene transfection and other biomedical applications. [50] Drug delivery: Multiple cellular stimuli could induce responses in supramolecular polymers.
Supramolecular chemistry refers to the branch of chemistry concerning chemical systems composed of a discrete number of molecules.The strength of the forces responsible for spatial organization of the system range from weak intermolecular forces, electrostatic charge, or hydrogen bonding to strong covalent bonding, provided that the electronic coupling strength remains small relative to the ...
A micelle (/ m aɪ ˈ s ɛ l /) or micella (/ m aɪ ˈ s ɛ l ə /) (pl. micelles or micellae, respectively) is an aggregate (or supramolecular assembly) of surfactant amphipathic lipid molecules dispersed in a liquid, forming a colloidal suspension (also known as associated colloidal system). [4]
The phospholipid amphiphiles are the major structural component of cell membranes. Amphiphiles are the basis for a number of areas of research in chemistry and biochemistry, notably that of lipid polymorphism. Organic compounds containing hydrophilic groups at both ends of the molecule are called bolaamphiphilic.
Mark W. Grinstaff (born May 23, 1965) is the William Fairfield Warren Distinguished Professor and a Professor of Biomedical Engineering, Chemistry, Materials Science and Engineering and Medicine, at Boston University, Director of the National Institutes of Health's T32 Program in Translational Research in Biomaterials and Director of Nanotechnology Innovation Center.
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential ...