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Positive-strand RNA viruses (+ssRNA viruses) are a group of related viruses that have positive-sense, single-stranded genomes made of ribonucleic acid. The positive-sense genome can act as messenger RNA (mRNA) and can be directly translated into viral proteins by the host cell's ribosomes. Positive-strand RNA viruses encode an RNA-dependent RNA ...
Sense (molecular biology) In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. [citation needed] Depending on the context, sense may have slightly different meanings.
Animal RNA viruses are classified by the ICTV. There are three distinct groups of RNA viruses depending on their genome and mode of replication: Double-stranded RNA viruses (Group III) contain from one to a dozen different RNA molecules, each coding for one or more viral proteins. Positive-sense ssRNA viruses (Group IV) have their genome ...
One defining feature is the use of reverse transcriptase to convert the positive-sense RNA into DNA. Instead of using the RNA for templates of proteins, they use DNA to create the templates, which is spliced into the host genome using integrase. Replication can then commence with the help of the host cell's polymerases.
The genome is a single-stranded positive-sense RNA (+ssRNA) genome that is about 7500 nucleotides long. [2] The viral particle is about 30 nm in diameter with icosahedral symmetry . Because of its short genome and its simple composition—only a strand of RNA and a nonenveloped icosahedral protein coat encapsulating it—poliovirus is widely ...
In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA.
When referring to DNA transcription, the coding strand (or informational strand[1][2]) is the DNA strand whose base sequence is identical to the base sequence of the RNA transcript produced (although with thymine replaced by uracil). It is this strand which contains codons, while the non-coding strand contains anticodons.
Lentiviral delivery of designed shRNA's and the mechanism of RNA interference in mammalian cells. Nucleic acid. Virions contain 2% nucleic acid; Genome consists of a dimer; Virions contain one molecule of (each) linear positive-sense single stranded RNA. Total genome length is of one monomer ranges from 8k-10k nt (depending on the virus).