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Pimecrolimus is an immunosuppressant drug of the calcineurin inhibitor class used in the treatment of atopic dermatitis (eczema). It is available as a topical cream. It was developed and formerly marketed by Novartis under the trade name Elidel .
Pimecrolimus is generally well tolerated with a rare side effect of a burning sensation at the application site. [27] Topical adapalene has been reported to resolve a case of perioral dermatitis in 4 weeks without any side effects. The dose used was 1% adapalene gel once a day at night.
An open-label pilot study found that topical pimecrolimus cream helped dark-skinned patients with postinflammatory hypopigmentation related to seborrheic dermatitis. [ 8 ] When functional melanocytes are present in the damaged area, sun or ultraviolet (UV) exposure may aid in repigmentation; however, excessive exposure may intensify the color ...
[1] Prevention of atopic dermatitis is typically with essential fatty acids, [4] and may be treated with moisturizers and steroid creams. [5] The steroid creams should generally be of mid-to high strength and used for less than two weeks at a time, as side effects can occur. [8] Antibiotics may be required if there are signs of skin infection. [2]
Side effects may occur from sudden discontinuation and prolonged, continuous use can lead to skin thinning. [2] Intermittent use of topical steroids for atopic dermatitis is safe and does not cause skin thinning.
Severe and chronic cases seldom respond sufficiently and require long periods of treatment which can increase the risk of side effects occurring. In individual cases, and especially in the case of atopic hand eczema, the dermatologist may prefer to use cortisone-free, anti-inflammatory creams or salves, which include calcineurin inhibitors ...
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