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Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. [2] The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease's most dangerous form, falciparum malaria.
However, the WHO has recommended that a single dose of primaquine (0.25 mg/kg) is safe to give even in individuals with G6PD deficiency, for the purpose of preventing transmission of P. falciparum malaria. [14] Primaquine is contraindicated in pregnancy, because the glucose-6-phosphate dehydrogenase status of the fetus would be unknown. [4]
This is a first fixed-dose artemisinin-based combination therapy to be granted a positive scientific opinion for efficacy, safety and quality from European Medicines Agency (EMA) under Article 58 for the treatment of P. falciparum and P. vivax in adults and children over 20 kg based on five multi-centre phase III trials conducted in Africa and ...
It is approved in the United States as a treatment and preventive measure against malaria. [6] The combination is considered to be more effective in treating malaria caused by Plasmodium falciparum than that caused by P. vivax, for which chloroquine is considered more effective, though in the absence of a species-specific diagnosis, the sulfadoxine-pyrimethamine combination may be indicated. [7]
Artemether is an antimalarial drug for uncomplicated malaria caused by P. falciparum (and chloroquine-resistant P. falciparum) or chloroquine-resistant P. vivax parasites. [1] [7] Artemether can also be used to treat severe malaria. [2] The World Health Organization (WHO) recommends the treatment of uncomplicated P. falciparum with artemisinin ...
Using substrate specificity studies and inhibitor analysis, it was found that the plasmepsins for P. malariae and P. vivax showed less specificity than that for P. falciparum. Unfortunately, this means that the development of a selective inhibitor for P. malariae may prove more challenging than the development of one for P. falciparum. [5]
Hence, its geographical distribution is overlapping with areas of high malaria prevalence rates and the occurrence of drug resistant Plasmodium falciparum. [5] P. falciparum is one of the four main protozoan parasites that cause malaria and is one of the leading causes of malaria deaths. This species complex is of high medical importance for ...
[1] [4] Chloroquine is a member of the drug class 4-aminoquinoline. [1] As an antimalarial, it works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell. [1] How it works in rheumatoid arthritis and lupus erythematosus is unclear. [1] Chloroquine was discovered in 1934 by Hans Andersag.