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This is a first fixed-dose artemisinin-based combination therapy to be granted a positive scientific opinion for efficacy, safety and quality from European Medicines Agency (EMA) under Article 58 for the treatment of P. falciparum and P. vivax in adults and children over 20 kg based on five multi-centre phase III trials conducted in Africa and ...
Artemisinin (/ ˌ ɑːr t ɪ ˈ m iː s ɪ n ɪ n /) and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. [1] It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. [2]
Artemether is an antimalarial drug for uncomplicated malaria caused by P. falciparum (and chloroquine-resistant P. falciparum) or chloroquine-resistant P. vivax parasites. [1] [7] Artemether can also be used to treat severe malaria. [2] The World Health Organization (WHO) recommends the treatment of uncomplicated P. falciparum with artemisinin ...
Artesunate/amodiaquine, sold under the trade name Camoquin among others, is a medication used for the treatment of malaria. [3] [4] It is a fixed-dose combination of artesunate and amodiaquine. [3] Specifically it recommended for acute uncomplicated Plasmodium falciparum malaria. [5] It is taken by mouth. [4]
Artesunate is the first-line treatment for children or adults with severe malaria, [16] [17] [18] usually in combination with another antimalarial drug. There is moderate-quality evidence that treatment with artesunate plus mefloquine is superior to treatment with artesunate plus amodiaquine or artesunate plus sulfadoxine-pyrimethamine. [19]
Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. [2] The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease's most dangerous form, falciparum malaria.
It is approved in the United States as a treatment and preventive measure against malaria. [6] The combination is considered to be more effective in treating malaria caused by Plasmodium falciparum than that caused by P. vivax, for which chloroquine is considered more effective, though in the absence of a species-specific diagnosis, the sulfadoxine-pyrimethamine combination may be indicated. [7]
Amodiaquine (ADQ) is a medication used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. [2] [3] It is recommended to be given with artesunate to reduce the risk of resistance. [2] Due to the risk of rare but serious side effects, it is not generally recommended to prevent malaria. [2]