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A liver injury, also known as liver laceration, is some form of trauma sustained to the liver. This can occur through either a blunt force such as a car accident, or a penetrating foreign object such as a knife. [1] Liver injuries constitute 5% of all traumas, making it the most common abdominal injury. [2]
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
Inflammatory cytokines (TNF-alpha, IL-6 and IL-8) are thought to be essential in the initiation and perpetuation of liver injury and cytotoxic hepatomegaly by inducing apoptosis and severe hepatotoxicity. One possible mechanism for the increased activity of TNF-α is the increased intestinal permeability due to liver disease.
Jaundice (when your skin or the whites of your eyes turn yellow due to liver damage) Swelling in your abdomen or legs. If fatty liver disease leads to cirrhosis, you might experience: Fatigue ...
Dr. Clarke notes that mild liver damage usually starts with loss of appetite and fatigue, while more acute or severe liver damage has other symptoms. If you ever notice that you have jaundice, see ...
Alcohol-induced epigenetic alterations of gene expression appear to lead to liver injury and ultimately carcinoma. [35] Obesity is associated with a higher risk of primary liver cancer. [36] As shown with mice, obese mice are prone to liver cancer, likely due to two factors. Obese mice have increased pro-inflammatory cytokines.