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“Early onset colorectal cancer (colon cancer in persons under age 50) is on the rise, but in absolute numbers, the risk is low. ... the median age of EOCRC diagnosis is 44 — so clearly, we ...
A diagnosis of colorectal cancer in patients under 50 years of age is referred to as early-onset colorectal cancer (EOCC). [178] [210] Instances of EOCC have increased over the last decade, specifically in patient populations aged 20 to 40 years old throughout North America, Europe, Australia, and China. [210] [211]
One study involving more than 1 million people with colon cancer from 2004 to 2015 found that 51.6% of those under 50 were diagnosed with stage three or four cancer, while 40% of people over 50 ...
Colon cancer rates for people under age 50 are going up across countries both rich and poor. In the US, rates for older adults are declining, while early-onset colon cancer is on the rise.
At least 3 relatives with histologically confirmed colorectal cancer, 1 of whom is a first degree relative of the other 2; familial adenomatous polyposis should be excluded; At least 2 successive generations involved; At least 1 of the cancers diagnosed before age 50. [5]
The incidence of the mutation is between 1 in 10,000 and 1 in 15,000 births. By age 35 years, 95% of individuals with FAP (>100 adenomas) have polyps. Without colectomy, colon cancer is virtually inevitable. The mean age of colon cancer in untreated individuals is 39 years (range 34–43 years). [13]