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Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. [ 1 ] Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to ...
Elixir sulfanilamide was an improperly prepared sulfonamide antibiotic that caused mass poisoning in the United States in 1937. It is believed to have killed 107 people. [ 1 ] The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act , which significantly increased ...
Sulfonamide functional group Hydrochlorothiazide is a sulfonamide and a thiazide. Furosemide is a sulfonamide, but not a thiazide. Sulfamethoxazole is an antibacterial sulfonamide. Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs.
The company was responsible for the elixir sulfanilamide disaster of 1937, described as one of the most consequential mass poisonings of the 20th century. [2] Elixir sulfanilamide was formulated with diethylene glycol as a solvent. The company claimed to have been unaware of the toxicity of diethylene glycol, despite the existence of published ...
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria.One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist.
1935 – Prontosil (an oral precursor to sulfanilamide), the first sulfonamide; 1936 – Sulfanilamide; 1938 – Sulfapyridine (M&B 693) 1939 – sulfacetamide; 1940 – sulfamethizole; 1942 – benzylpenicillin, the first penicillin; 1942 – gramicidin S, the first peptide antibiotic; 1942 – sulfadimidine; 1943 – sulfamerazine
Elixir Sulfanilamide 105 adults and children died from diethylene glycol in over 14 states from a toxic version of sulfanilamide created by the S.E Massengill's company marked as the 'Elixir of sulfanilamide.' 1964, The whole planet earth.
The book went through the history of sulfanilamide, chemotherapy of experimental bacterial infections, the toxicity and comparative pharmacology of sulfanilamide, the mode of action of sulfanilamide, the clinical use of sulfanilamide (and others), the clinical use of Prontosil and Neoprontosil, as well as the clinical and toxic manifestations ...