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Then it turns north and crosses I-95. Just before the town of Santee, US 15 converges with US 301. In Santee, the two highways merge with I-95 at exit 98 and all three cross Lake Marion. At exit 102, US 15/US 301 split off from I-95 and go into the town of Summerton. US 15 then separates from US 301 and heads mainly north to city of Sumter.
U.S. Highway 15 Connector (US 15 Conn.) is a 2.140-mile (3.444 km) connector route that connects US 15/US 301 at the SCHP Patrolman Harry B. Ray Memorial Intersection just southwest of Santee, South Carolina, with South Carolina Highway 6 (SC 6) in the northeastern part of the town.
US 15/US 501 turns left in Durham. From the South Carolina state line, US 15 is in concurrency with US 401 to Laurinburg.Merging with US 501, it becomes what is known as "15-501" ("Fifteen Five-o-one"), a concurrency that extends for 106 miles (171 km) across central North Carolina; US 15 also the dominant partner, using its milemarkers along the route.
As the routes turn east, the roadway continues north as US 15 Connector to service Santee. [9] In Santee, the two highways merge with I-95 at exit 98 and all three cross Lake Marion . At exit 102, US 15/US 301 split off from I-95 returning to the former segment of US 15/US 301, now named St. Paul Road and go into the town of Summerton .
US 15 / US 301 near Santee. The highways travel concurrently to Santee. US 521 near Manning US 378 near Turbeville US 76 in Florence I-20 in Florence US 52 near Florence North Carolina US 301 / US 501 near Rowland US 301 near Rowland. The highways travel concurrently to Lumberton. I-74 / US 74 near Lumberton I-295 / US 13 in Eastover US 421 in Dunn
US 301 at the SC 260 intersection in Manning.. US 301 was established in 1932 as a replacement of the piece of US 17-1 north of Wilson and the whole of US 217. Thus US 301 initially ran from US 17 (now US 76) at Pee Dee northeast through Dillon, South Carolina, into North Carolina, and Virginia, ending at U.S. Route 1 in Petersburg, Virginia.
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In South Carolina it ran along US 15 southwest to Santee, South Carolina and replaced SC 4 west to Orangeburg, South Carolina. From Orangeburg, US 301 ran southwest with US 601 to Bamberg, South Carolina, replaced SC 33 to Ulmer, South Carolina, replaced SC 508 to Allendale, South Carolina, and replaced SC 73 to the Georgia state line. [3]