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Approximately 15–50% of people who suddenly stop an antidepressant develop antidepressant discontinuation syndrome. [7] [2] [3] [4] The condition is generally not serious, [2] though about half of people with symptoms describe them as severe. [4] Many restart antidepressants due to the severity of the symptoms. [4]
Pregabalin may help reduce the severity of benzodiazepine withdrawal symptoms, [108] and reduce the risk of relapse. [109] Propranolol was not found to increase the discontinuation success rate. [86] SSRI antidepressants have been found to have little value in the treatment of benzodiazepine withdrawal. [110]
The stopping of antidepressants for example, can lead to antidepressant discontinuation syndrome. With careful physician attention, however, medication prioritization and discontinuation can decrease costs, simplify prescription regimens, decrease risks of adverse drug events and poly-pharmacy, focus therapies where they are most effective, and ...
Don’t ever adjust your dosage or stop taking your antidepressant without talking to your healthcare provider or prescriber. Changing your dosage or abruptly stopping your medication could ...
Anticonvulsant medications, such as gabapentin and pregabalin, may help to treat symptoms of certain anxiety disorders, such as generalized anxiety disorder and social anxiety disorder. In many ...
gabapentinoids such as gabapentin (Neurontin), pregabalin (Lyrica), and phenibut (Noofen), which are inhibitors of α 2 δ subunit-containing VDCCs Tooltip voltage-dependent calcium channels [17] [18] antiepileptic drugs such as valproate, lamotrigine, tiagabine, vigabatrin, carbamazepine and oxcarbazepine, and topiramate [17] [19] [20]
Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [19] [20] as well as sexual dysfunction. [6] [21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [22]
Another example of pharmaceutical rebound is a rebound headache from painkillers when the dose is lowered, the medication wears off, or the drug is abruptly discontinued. [ 18 ] In 2022, reports of viral RNA and symptom rebound in people with COVID-19 treated with Paxlovid were published.