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A meta-analysis found that ultrasound therapy is effective in reducing pain, increasing ROM, and reducing WOMAC functional scores in patients with knee osteoarthritis. [7] There are three potential therapeutic mechanisms of ultrasound in physical therapy. The first is the increase in blood flow in the treated area.
Ultrasound imaging deposits energy over a large area while therapeutic ultrasound focuses the energy on one target site. Focused ultrasound for intracrainial drug delivery is a non-invasive technique that uses high-frequency sound waves (focused ultrasound, or FUS) to disrupt tight junctions in the blood–brain barrier (BBB), allowing for increased passage of therapeutics into the brain.
These techniques are known as Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) [31] [32] and Ultrasound guided Focused Ultrasound Surgery (USgFUS) respectively. [1] [33] MRgFUS is a 3D imaging technique which features high soft tissue contrast and provides information about temperature, thus allowing to monitor ablation.
Medical ultrasound includes diagnostic techniques (mainly imaging techniques) using ultrasound, as well as therapeutic applications of ultrasound. In diagnosis, it is used to create an image of internal body structures such as tendons, muscles, joints, blood vessels, and internal organs, to measure some characteristics (e.g., distances and velocities) or to generate an informative audible sound.
Typical diagnostic ultrasound machines operate in the frequency range of 2-18 megahertz, whereas home ultrasound machines and therapeutic ultrasound machines operate in the frequency range of .7-3.3 megahertz. Diagnostic sonography is typically used to create an audio "image", such as during pregnancy to visualize the developing baby.
The mechanism of action for sonodynamic therapy is the use of low-intensity ultrasound through the use of focused mechanical waves to create a cytotoxic effect. However, SDT itself is non-thermal, non-toxic, and is able to non-invasively penetrate deep into tissue compared to other delivery methods such as photodynamic therapy.
Transcranial pulsed ultrasound (TPU) uses low intensity, low frequency ultrasound (LILFU) to stimulate the brain. In 2002, Dr. Alexander Bystritsky first proposed the idea that this methodology contained therapeutic benefits. [ 1 ]
Contrast-enhanced ultrasound (CEUS) is the application of ultrasound contrast medium to traditional medical sonography. Ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances. This may be the surface of a small air bubble or a more complex structure.