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Zombie cells are thought to build up in all manner of tissues, but they don’t seem to necessarily behave the same way in one part of the body that they do in another.
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It’s built upon the idea that cells eventually stop dividing and enter a “senescent” state in response to various forms of damage. The body removes most of them. But others linger like zombies.
Possible senolytic agents are under preliminary research, including some which are in early-stage human trials. [6] [7] [clarification needed] The majority of candidate senolytic compounds are repurposed anti-cancer molecules, such as the chemotherapeutic drug dasatinib and the experimental small molecule navitoclax.
Natural killer cells (NK cells) and macrophages play a major role in clearance of senescent cells. [65] Natural killer cells directly kill senescent cells, and produce cytokines which activate macrophages which remove senescent cells. [65] Senescent cells can be phagocytized by neutrophils as well as by macrophages. [66]
In humans with non-injured tissues, the tissue naturally regenerates over time; by default, new available cells replace expended cells. For example, the body regenerates a full bone within ten years, while non-injured skin tissue is regenerated within two weeks. [2] With injured tissue, the body usually has a different response.
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The liver and kidney are naturally capable of detox, as are intracellular (specifically, inner membrane of mitochondria or in the endoplasmic reticulum of cells) proteins such as CYP enzymes. In cases of kidney failure , the action of the kidneys is mimicked by dialysis ; kidney and liver transplants are also used for kidney and liver failure ...