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Lack of CDKN1B expression appears to release the hair cells from natural cell-cycle arrest. [ 42 ] [ 43 ] Because hair cell death in the human cochlea is a major cause of hearing loss , the CDKN1B protein could be an important factor in the clinical treatment of deafness .
B-cell prolymphocytic leukemia, referred to as B-PLL, is a rare blood cancer.It is a more aggressive, but still treatable, form of leukemia.. Specifically, B-PLL is a prolymphocytic leukemia (PLL) that affects prolymphocytes – immature forms of B-lymphocytes and T-lymphocytes – in the peripheral blood, bone marrow, and spleen.
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
Indisulam is a chloroindolyl sulfonamide cell cycle inhibitor that exhibits antitumor activity in vitro and in an animal model. [1] [2] [3] This compound affects cell cycle progression in human tumor cells and is being studied for the treatment of cancers such as melanomas and blood-borne cancers such as leukemia.
Absence of p53, the most commonly mutated gene in human cancer, has a major effect on cell cycle checkpoint regulators and has been shown to act at the G1 checkpoint in the past, but now appears to be important in regulating the spindle checkpoint as well. [76] Another key aspect of cancer is inhibition of cell death or apoptosis.
This system uses numerals I, II, III, and IV (plus the 0) to describe the progression of cancer. Stage 0: carcinoma in situ, abnormal cells growing in their normal place ("in situ" from Latin for "in its place"). Stage 0 can also mean no remaining cancer after preoperative treatment in some cancers (e.g. colorectal cancer).
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