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5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss. They are also sometimes used to treat excess hair growth in women and as a component of hormone therapy for transgender ...
Finasteride belongs to a class of medications called 5-alpha-reductase inhibitors (5ARIs). ... Try hair supplements. ... Finasteride can come with side effects.
As a 5-alpha-reductase inhibitor, finasteride works by inhibiting the effects of the enzyme responsible for converting testosterone into dihydrotestosterone (DHT).
This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
A small risk of gynecomastia has been associated with 5α-reductase inhibitors (1.2–3.5%). [36] [41] Based on reports of 5α-reductase type 2 deficiency in males and the effectiveness of 5α-reductase inhibitors for hirsutism in women, reduced body and/or facial hair growth is a likely potential side effect of these drugs in men.
Finasteride is one of two 5-alpha reductase inhibitors, along with dutasteride. 5-alpha reductase is an enzyme that your body eventually converts into a hormone called dihydrotestosterone (DHT).
A 2018 meta-analysis found no higher risk of breast cancer with 5α-reductase inhibitors. [33] Sexual and mood side effects, such as erectile dysfunction, [34] loss of libido, [35] depression, [36] and reduced semen volume occur in as many as 4.8% of patients taking 5α-reductase inhibitors including dutasteride.
Androgenetic alopecia is caused by a combination of factors including genetic predisposition and the effects of male sex hormones called androgens. ... a 5-alpha reductase inhibitor. In simpler ...