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20666 Ensembl ENSG00000176887 ENSMUSG00000063632 UniProt P35716 Q7M6Y2 RefSeq (mRNA) NM_003108 NM_009234 RefSeq (protein) NP_003099 NP_033260 Location (UCSC) Chr 2: 5.69 – 5.7 Mb Chr 12: 27.38 – 27.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene. Function This intronless gene encodes a member ...
CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of: CHOP consists of: C yclophosphamide , an alkylating agent which damages DNA by binding to it and causing the formation of cross-links
For diffuse large B-cell lymphoma, the standard treatment includes cyclophosphamide, doxorubicin, vincristine, and prednisone . Adding rituximab , a monoclonal antibody targeting the CD20 B-cell antigen, to the CHOP regimen has been shown to improve complete-response rates and extend event-free and overall survival in elderly patients without ...
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, comprising about 6% of cases. [1] [2] It is named for the mantle zone of the lymph nodes where it develops. [3] [4] The term 'mantle cell lymphoma' was first adopted by Raffeld and Jaffe in 1991. [5]
In Burkitt's lymphoma and mantle cell lymphoma, the other protein in the fusion is c-myc (on chromosome 8) and cyclin D1 [9] (on chromosome 11), respectively, which gives the fusion protein pro-proliferative ability. In follicular lymphoma, the fused protein is Bcl-2 (on chromosome 18), which gives the fusion protein anti-apoptotic abilities.
ICE in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin's lymphoma and Hodgkin lymphoma. In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab. This regimen is then called ICE-R or R-ICE or RICE.
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