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WNT1-inducible-signaling pathway protein 1 (WISP-1), [5] is a member of the CCN protein family and should correctly be referred to as CCN4 as suggested by the International CCN Society. [6] It is a matricellular protein that in humans is encoded by the WISP1 gene .
WISP-2 is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. The CCN acronym is derived from the first three members of the family identified, namely CYR61 (CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV .
327743 Ensembl ENSG00000112761 ENSMUSG00000062074 UniProt O95389 D3Z5L9 RefSeq (mRNA) NM_003880 NM_130396 NM_198239 NM_001127376 RefSeq (protein) NP_003871 NP_937882 NP_001120848 Location (UCSC) Chr 6: 112.05 – 112.07 Mb Chr 10: 39.15 – 39.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular ...
When Wnt1 was discovered, it was first identified as a proto-oncogene in a mouse model for breast cancer. The fact that Wnt1 is a homolog of Wg shows that it is involved in embryonic development, which often calls for rapid cell division and migration. Misregulation of these processes can lead to tumor development via excess cell proliferation.
7471 22408 Ensembl ENSG00000125084 ENSMUSG00000022997 UniProt P04628 P04426 RefSeq (mRNA) NM_005430 NM_021279 RefSeq (protein) NP_005421 NP_067254 Location (UCSC) Chr 12: 48.98 – 48.98 Mb Chr 15: 98.69 – 98.69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 (INT1) gene. The ...
Wnt1 is mainly expressed in the entire midbrain (Otx2 expressing cells) at first. [5] Once the midbrain/hindbrain boundary has formed, Wnt1 expression localizes to the roof plate of the neural tube and to the posterior region of the midbrain. At the MHB, Wnt1 plays a role in cell proliferation and also maintains the FGF8 expression.
In 1982, Nusse and Varmus discovered the Wnt1 gene. [3] After his postdoctoral fellowship, Nusse joined the Netherlands Cancer Institute expanding on the earlier work on the Wnt pathway and identifying the pathway in fruit flies. In 1990, he joined the department of Developmental Biology at Stanford University. His lab is currently focused on ...
6496 20473 Ensembl ENSG00000138083 ENSMUSG00000038805 UniProt O95343 Q62233 RefSeq (mRNA) NM_005413 NM_011381 RefSeq (protein) NP_005404 NP_035511 Location (UCSC) Chr 2: 44.94 – 44.95 Mb Chr 17: 85.92 – 85.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene. Function The SIX homeobox 3 (SIX3) gene is ...