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The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD 50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD 50 is indicative of higher toxicity. The term LD 50 is generally attributed to John William Trevan. [2]
Oral Toxicity: LD 50 for acute oral toxicity means that dose of the material administered to both male and female young adult albino rats which causes death within 14 days in half the animals tested. The number of animals tested must be sufficient to give statistically valid results and be in conformity with good pharmacological practices.
It is calculated using the LD50 or LC50. [1] The Occupational Safety and Health Administration (OSHA) regulation (1910.134(b)) defines the term as "an atmosphere that poses an immediate threat to life, would cause irreversible adverse health effects, or would impair an individual's ability to escape from a dangerous atmosphere."
In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation.Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die.
An example SDS, including guidance for handling a hazardous substance and information on its composition and properties. A safety data sheet (SDS), [1] material safety data sheet (MSDS), or product safety data sheet (PSDS) is a document that lists information relating to occupational safety and health for the use of various substances and products.
A shipping container with nuclear fuel being loaded in Serbia. It is recommended to governments for adoption or for use as the basis for national regulations and is mandatory in conjunction with the obligations of the members of the United Nations under the International Convention for the Safety of Life at Sea (SOLAS) and the International Convention for the Prevention of Pollution from Ships ...
Substances are assigned to one of the five toxicity categories on the basis of LD 50 (oral, dermal) or LC 50 (inhalation). Skin corrosion means the production of irreversible damage to the skin following the application of a test substance for up to 4 hours. Substances and mixtures in this hazard class are assigned to a single harmonized ...
The Code is designed to minimise the dangers to ship from carrying solid bulk cargoes. [2] It provides information on the dangers of cargo, as well as procedures for loading and unloading of cargoes. [2]