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For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug. [3] AUC becomes useful for knowing the average concentration over a time interval, AUC/t.
AUC is used because AUC is proportional to the dose that has entered the systemic circulation. [ 5 ] Bioavailability of a drug is an average value ; to take population variability into account, deviation range is shown as ± . [ 4 ]
Whereas ROC AUC varies between 0 and 1 — with an uninformative classifier yielding 0.5 — the alternative measures known as Informedness, [citation needed] Certainty [23] and Gini Coefficient (in the single parameterization or single system case) [citation needed] all have the advantage that 0 represents chance performance whilst 1 ...
There are various competing calculation methods for the drug accumulation ratio, yielding somewhat different results. A commonly used formula defines R ac as the ratio of the area under the curve (AUC) during a single dosing interval under steady state conditions to the AUC during a dosing interval after one single dose: [1]
Noncompartmental methods are versatile in that they do not assume any specific model and generally produce accurate results acceptable for bioequivalence studies. Total drug exposure is most often estimated by area under the curve (AUC) methods, with the trapezoidal rule (numerical integration) the most common method.
They do that when cold high pressure builds in western Canada and then is let loose by upper-level winds that flow southward into the Plains. This dense, flowing cold air banks against the eastern ...
When measuring diagnostic ability, a commonly reported measure is the area under the curve (AUC). The AUC is calculable from the TOC and the ROC. The value of the AUC is consistent for the same data whether you are calculating the area under the curve for a TOC curve or a ROC curve.
Kristin Davis is looking back on her Melrose Place days. In the latest PEOPLE cover story, the Sex and the City alum, 59, reflects on her storied career in television and gets candid about the ...