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The crystal structures of FGF1 have been solved and found to be related to interleukin 1-beta. Both families have the same beta trefoil fold consisting of 12-stranded beta-sheet structure, with the beta-sheets are arranged in 3 similar lobes around a central axis, 6 strands forming an anti-parallel beta-barrel.
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [ 5 ] [ 6 ] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins , themselves a family of closely related molecules.
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. [5] [6] It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein.
21808 Ensembl ENSG00000092969 ENSMUSG00000039239 UniProt P61812 P27090 RefSeq (mRNA) NM_003238 NM_001135599 NM_009367 NM_001329107 RefSeq (protein) NP_001129071 NP_003229 NP_001316036 NP_033393 Location (UCSC) Chr 1: 218.35 – 218.44 Mb Chr 1: 186.35 – 186.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as ...
A bone growth factor is a growth factor that stimulates the growth of bone tissue. [1] [2]Known bone growth factors include insulin-like growth factor-1 (IGF-1), insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid hormone-related peptide (PTHrP), bone morphogenetic proteins (BMPs ...
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family.
They each have an N-terminal signal peptide of 20–30 amino acids that they require for secretion from a cell, a pro-region called latency-associated peptide (LAP - Alias: Pro-TGF beta 1, LAP/TGF beta 1), and a 112-114 amino acid C-terminal region that becomes the mature TGF-β molecule following its release from the pro-region by proteolytic ...
[1] [2] The natural alternate splicing of four fibroblast growth factor receptor (FGFR) genes results in the production of over 48 different isoforms of FGFR. [ 3 ] These isoforms vary in their ligand-binding properties and kinase domains, however all share the common extracellular region composed of three immunoglobulin (Ig)-like domains (D1 ...