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The fecal elastase test measures the concentration of the elastase-3B enzyme found in fecal matter with an enzyme-linked immunosorbent assay . Results of this test can give a good indication of exocrine pancreatic status, and the test is less invasive and expensive than the current "gold standard" , secretin-cholecystokinin test. [ 9 ]
Pancreatic elastase is a compact globular protein with a hydrophobic core. This enzyme is formed by three subunits. Each subunit binds one calcium ion ().There are three important metal-binding sites in amino acids 77, 82, 87. [4]
A fecal pH test may be used to determine lactose intolerance or the presence of an infection. [13] Steatorrhea can be diagnosed using a fecal fat test, which checks for the malabsorption of fat. [14] Faecal elastase levels are becoming the mainstay of pancreatitis diagnosis.
In molecular biology, elastase is an enzyme from the class of proteases (peptidases) that break down proteins, [1] specifically one that can break down elastin. In other words, the name only refers to the substrate specificity (i.e. what proteins it can digest), not to any kind of evolutionary grouping.
Other tests include the (13)C-mixed triglycerides test and fecal elastase, to detect possible fat maldigestion due to exocrine pancreatic insufficiency, [14] or various specific tests to detect other causes of malabsorption such as celiac disease. [15]
Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas.EPI can occur in humans and is prevalent in many conditions [1] such as cystic fibrosis, [2] Shwachman–Diamond syndrome, [3] different types of pancreatitis, [4] multiple types of diabetes mellitus (Type 1 and Type 2 diabetes), [5] advanced ...
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In chronic pancreatitis, the fecal pancreatic elastase-1 (FPE-1) test is a marker of exocrine pancreatic function. Additional tests that may be useful in evaluating chronic pancreatitis include hemoglobin A1C , immunoglobulin G4 , rheumatoid factor , and anti-nuclear antibody .