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Many MC proteins preferentially catalyze the exchange of one solute for another ().A variety of these substrate carrier proteins, which are involved in energy transfer, have been found in the inner membranes of mitochondria and other eukaryotic organelles such as the peroxisome and facilitate the transport of inorganic ions, nucleotides, amino acids, keto acids and cofactors across the membrane.
The amount of mitochondria per cell also varies by cell type, with some examples being: Erythrocytes: 0 mitochondria per cell. [1] Lymphocytes: 3 mitochondria per cell. [7] Egg cell: Mature metaphase II egg cells can contain 100,000 mitochondria, and 50,000–1,500,000 copies of the mitochondrial genome (corresponding to up to 90% of the egg ...
Depiction of mitochondrial membranes. [1] Mitochondrial membrane transport proteins, also known as mitochondrial carrier proteins, are proteins which exist in the membranes of mitochondria. They serve to transport [2] molecules and other factors, such as ions, into or out of the organelles. Mitochondria contain both an inner and outer membrane ...
Mitoferrin-1 (Mfrn1) is a 38 kDa protein [5] that is encoded by the SLC25A37 gene in humans. [6] [7] It is a member of the Mitochondrial carrier (MC) Superfamily, however, its metal cargo makes it distinct from other members of this family.
Human cells express four ADP/ATP translocases: SLC25A4, SLC25A5, SLC25A6 and SLC25A31, which constitute more than 10% of the protein in the inner mitochondrial membrane. [6] These proteins are classified under the mitochondrial carrier superfamily.
13358 Ensembl ENSG00000100075 ENSMUSG00000003528 UniProt P53007 Q8JZU2 RefSeq (mRNA) NM_001256534 NM_001287387 NM_005984 NM_153150 RefSeq (protein) NP_001243463 NP_001274316 NP_005975 NP_001243463.1 NP_001274316.1 NP_694790 Location (UCSC) Chr 22: 19.18 – 19.18 Mb Chr 16: 17.74 – 17.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tricarboxylate transport protein, mitochondrial ...
The carrier preprotein is then inserted into the inner mitochondrial membrane in a potential-dependent fashion. [10] The membrane potential is necessary for both insertion of the precursor into the carrier translocase and lateral release of the protein into the lipid phase of the inner mitochondrial membrane, which completes protein translocation.
Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene. [ 5 ] [ 6 ] The encoded protein is a transmembrane protein located in the mitochondrial inner membrane and catalyzes the transport of phosphate ions across it for the purpose of oxidative phosphorylation .